Microbiome Research using Next Generation Sequencing

Professor Joseph F Petrosino, Chief Scientific Officer at Metanome and Director of the Alkek Center for Metagenomics and Microbiome Research at Baylor College of Medicine, discusses how the Human Microbiome Project aims to characterize the human microbiome and analyze its role in human health and disease.

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The Positive Role of Bacteria on the Human Microbiome

The positive role of bacteria on the human microbiome – an interview with Professor Joseph F Petrosino, Chief Scientific Officer at Metanome and Director of the Alkek Center for Metagenomics and Microbiome Research at Baylor College of Medicine.

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Metanome Selected as Metagenomics Provider for Seres Health Clinical Trial

“Metanome, Inc. has been a valuable corporate collaborator in our studies of the human microbiome delivering high-quality, genomic data in a timely manner. I’ve appreciated their responsiveness and willingness to work with Seres Health on meeting our various genomic characterization needs and look forward to continuing to work with Metanome to support our future sequencing efforts.” – Dr. Matthew Henn, Head of Therapeutic Design at Seres Health

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What is Your Gut Telling You?

Scientists have long studied the link between our genes and our health. Now, in a growing area of scientific research, they’re studying the link between the bacteria in our intestines and virtually every disease that ails us.

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Using the Gut Microbiome to Improve Health

Scientists analyzing the gut microbiome have found groups of bacteria that are either abundant or nearly absent – a finding that could aid in coming up with ways to intervene to improve a person’s health. Though there is gradual variation in the abundance of much of gut bacteria, the scientists said in this week’s issue of the journal Nature Communications, specific bacterial groups exist in stable configurations that are associated with a person’s physiology and health.

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Architectural Design Drives the Biogeography of Indoor Bacterial Communities

Architectural design has the potential to influence the microbiology of the built environment, with implications for human health and well-being, but the impact of design on the microbial biogeography of buildings remains poorly understood. In this study we combined microbiological data with information on the function, form, and organization of spaces from a classroom and office building to understand how design choices influence the biogeography of the built environment microbiome.

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The Human Gut Microbiome as a Screening Tool for Colorectal Cancer

Recent studies have suggested that the gut microbiome may be an important factor in the development of colorectal cancer. Abnormalities in the gut microbiome have been reported in patients with colorectal cancer; however, this microbial community has not been explored as a potential screen for early-stage disease. We characterized the gut microbiome in patients from three clinical groups representing the stages of colorectal cancer development: healthy, adenoma, and carcinoma. Analysis of the gut microbiome from stool samples revealed both an enrichment and depletion of several bacterial populations associated with adenomas and carcinomas.

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Conducting a Microbiome Study

Human microbiome research is an actively developing area of inquiry, with ramifications for our lifestyles, our interactions with microbes, and how we treat disease.  Advances depend on carefully executed, controlled, and reproducible studies.  Here, we provide a Primer for researchers from diverse disciplines interested in conducting microbiome research. We discuss factors to be considered in the design, execution, and data analysis of microbiome studies.  These recommendations should help researchers to enter and contribute to this rapidly developing field.

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